Macrophage Sortilin Promotes LDL Uptake, Foam Cell Formation, and Atherosclerosis
نویسندگان
چکیده
منابع مشابه
Macrophage sortilin promotes LDL uptake, foam cell formation, and atherosclerosis.
RATIONALE Noncoding gene variants at the SORT1 locus are strongly associated with low-density lipoprotein cholesterol (LDL-C) levels, as well as with coronary artery disease. SORT1 encodes a protein called sortilin, and hepatic sortilin modulates LDL metabolism by targeting apolipoprotein B-containing lipoproteins to the lysosome. Sortilin is also expressed in macrophages, but its role in macro...
متن کاملMacrophage sortilin promotes LDL uptake, foam cell formation, and atherosclerosis (p 789) Sortilin protein drives cholesterol uptake in macrophages and promotes
Sortilin protein drives cholesterol uptake in macrophages and promotes atherosclerosis, report Patel et al. A characteristic feature of atherosclerosis is the formation of foam cells that arise from cholesterol-loaded macrophages. But exactly how macrophages take up cholesterol from transporter proteins such as low-density lipoprotein (LDL) is unclear, especially since the deletion of known mac...
متن کاملMacrophage sortilin promotes LDL uptake, foam cell formation, and atherosclerosis (p 789) Sortilin protein drives cholesterol uptake in macrophages and promotes
Sortilin protein drives cholesterol uptake in macrophages and promotes atherosclerosis, report Patel et al. A characteristic feature of atherosclerosis is the formation of foam cells that arise from cholesterol-loaded macrophages. But exactly how macrophages take up cholesterol from transporter proteins such as low-density lipoprotein (LDL) is unclear, especially since the deletion of known mac...
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Macrophage foam cells are a defining pathologic feature of atherosclerotic lesions. Recent studies have demonstrated that at high concentrations associated with hypercholesterolemia, native LDL induces macrophage lipid accumulation. LDL particles are taken up by macrophages as part of bulk fluid pinocytosis. However, the uptake and metabolism of cholesterol from native LDL during foam cell form...
متن کاملMacrophage Liver Kinase B1 Inhibits Foam Cell Formation and Atherosclerosis.
RATIONALE LKB1 (liver kinase B1) is a serine/threonine kinase and tumor suppressor, which regulates the homeostasis of hematopoietic cells and immune responses. Macrophages transform into foam cells upon taking-in lipids. No role for LKB1 in foam cell formation has previously been reported. OBJECTIVE We sought to establish the role of LKB1 in atherosclerotic foam cell formation. METHODS AND...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2015
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.116.305811